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- Rehabilitation Measures Database
- Chronic Respiratory Disease Questionnaire
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Purpose
The Chronic Respiratory Disease Questionnaire is a disease-specific health-related quality of life questionnaire.It was developed to measure the impact of Chronic Obstructive Pulmonary Disease (COPD) on a person’s life.
Link to Instrument
Acronym CRQ
Area of Assessment
Quality of Life
Assessment Type
Patient Reported Outcomes
Administration Mode
Paper & Pencil
Cost
Not Free
Cost Description
License agreement is required. Information can be found on the American Thoracic Society Website.
Diagnosis/Conditions
- Pulmonary Disorders
Populations
Pulmonary Diseases
Non-Specific Patient Population
Key Descriptions
- Consists of 20 items across four dimensions: dyspnea, fatigue, emotional function, and mastery.
- Originally was administered bya clinician, but has since been modified to a self-report measure.
- The dyspnea portion is individualized to each person: the person is asked to select the 5 activities associated with breathlessness that they perform frequently and are most important to them.
- Dyspnea items may be selected from a list of 26 suggested items or may be written in by the patients.
- Items in each section are scored from 1 (most severe) to 7 (no impairment).
Number of Items
20
Equipment Required
- Copy of questionnaire
- pen/pencil
Time to Administer
15-30minutes
30 minutes for first administration
15 minutes for subsequent administrations
Required Training
No Training
Age Ranges
Adult
18 - 64
years
Elderly Adult
65 +
years
Instrument Reviewers
Initially reviewedby Jason Barbas, PT, DPT, NCS in1/2010.
ICF Domain
Body Function
Measurement Domain
General Health
Considerations
Do you see an error or have a suggestion for this instrument summary? Pleasee-mail us!
Pulmonary Diseases
back to PopulationsMinimally Clinically Important Difference (MCID)
COPD:(Redelmeier et al, 1996;n= 112 patients with COPD who were participating ina supervised respiratory rehabilitation and in stable health; mean age = 67 (10) years)
- MCID = a change of 0.5 per item
Normative Data
COPD: (Rutten-van Molken et al, 1999; n = 144 patients with COPD, broken into three treatment groups; n = 47 taking Salmeterol and Ipatropium Bromide, 47 taking Salmeterol and placebo, and 50 taking placebo and placebo; mean age by treatment group = 63(7.1), 65.4(5.8) and 63.2(7.4) years)
Baseline characteristics of the study population
Normative Data of Study Population: | ||
Rehabilitation group | Control group | |
n | 28 | 15 |
Gender M/F | 23/5 | 14/1 |
Age yrs | 64(5) | 62(5) |
FEV bl | 1.2(0.3) | 1.2(0.3) |
FEV1al | 1.3(0.4) | 1.4(0.3) |
FEV1 % pred | 44(11) | 45(9) |
FEV1/IVC % | 39(8) | 36(7) |
IVC % pred | 84(16) | 94(15)* |
TLC %pred | 118(14) | 114(11) |
RV/TLC % pred | 151(24) | 133(18)* |
Cstl·kPa-1 | 4.3(3.1) | 5.3(3.0) |
TLCO/VA % pred | 65(23) | 65(25) |
All value are expressed as mean±SD. *: p<0.05 unpaired ttest. FEV1b: forced expiratory volume in one second before bronchodilation with two inhalations of 40 μg ipratropium bromide; FEV1a: FEV1 after bronchodilation; % pred: expressed as a percentage of the predicted value; FEV1/IVC %: FEV1 expressed as a percentage of the slow inspiratory vital capacity; TLC: total lung capacity; RV: residual volume; Cst: static lung compliance; TLCO/VA: transfer factor for carbon monoxide divided by alveolar volume.
Test/Retest Reliability
COPD:(Wijkstra et al, 1994;n= 43 patient with severe airflow obstruction; mean age = 64(5) years for the rehab group and 62(5) for the control group)
- Excellenttest re-test reliability (rho = 0.90)
COPD: (Williams, 2001;n= 52 patients with COPD; mean age = 66.5(7.9) years)
- Excellenttest re-test reliability for all four dimensions(ICC = 0.83-0.95)
Internal Consistency
COPD:(Wijkstra et al, 1994)
- Adequateto excellentinternal consistency for all four dimensions(Cronbach's alpha = 0.71-0.88)
COPD:(Harper et al, 1997;n =76 men and 80 women with COPD attending routine outpatient clinic; mean age = 67(10.4) years for men and 62(10.3) years for women)
- Excellentinternal consistency for all four dimensions(Cronbach's alpha = 0.8-0.85)
COPD:(Rutten-van Molken et al, 1999)
- Excellentinternal consistency (Chronbach's alpha = 0.84)
COPD:(Hajiro et al, 1998;n= 143 men with COPD; mean age = 68.8(6.9) years)
- Excellentinternal consistency (Chronbach's alpha = 0.90)
Construct Validity
COPD:(Hajiro et al, 1998)
Adequateconstruct validity with SCL-90 and SGR (r= 0.74-0.86)
Content Validity
COPD:(Wijkstra et al, 1994)
- Poor correlations between CRQ and lung function (PFTs)
- Poor correlations between CRQ and exercise capacity (6MW, CPET)
Responsiveness
Chronic airflow limitation:(Guyatt et al, 1987;n= 100 patients with chronic airflow limitation)
- Responsiveness was tested by administering the questionnaire to 13 patients before and after their drug treatment and to another 28 before and after participation in a respiratory rehabilitation program
There were statistically significant improvements in all four dimensions
Non-Specific Patient Population
back to PopulationsMinimal Detectable Change (MDC)
Quality of life:(Jaeschke et al, 1989;a literature review ofquality of life instruments)
A change in the score of 0.5 on the 7 point scale reflects a clinically significant small change
A change of 1.0 reflects a moderate change
A difference of 1.5 represents a large change
Minimally Clinically Important Difference (MCID)
Quality of life:(Jaeschke, 1989)
- MCID = a change of 0.5 per item
Bibliography
Guyatt, G. H., Berman, L. B., et al. (1987). "A measure of quality of life for clinical trials in chronic lung disease." Thorax 42(10): 773-778.Find it on PubMed
Hajiro, T., Nishimura, K., et al. (1998). "Comparison of discriminative properties among disease-specific questionnaires for measuring health-related quality of life in patients with chronic obstructive pulmonary disease." Am J Respir Crit Care Med 157(3 Pt 1): 785-790.Find it on PubMed
Harper, R., Brazier, J. E., et al. (1997). "Comparison of outcome measures for patients with chronic obstructive pulmonary disease (COPD) in an outpatient setting." Thorax 52(10): 879-887.Find it on PubMed
Jaeschke, R., Singer, J., et al. (1989). "Measurement of health status. Ascertaining the minimal clinically important difference." Control Clin Trials 10(4): 407-415.Find it on PubMed
). "Assessing the minimal important difference in symptoms: a comparison of two techniques." J Clin Epidemiol 49(11): 1215-1219.Find it on PubMed
Rutten-van Molken, M., Roos, B., et al. (1999). "An empirical comparison of the St George's Respiratory Questionnaire (SGRQ) and the Chronic Respiratory Disease Questionnaire (CRQ) in a clinical trial setting." Thorax 54(11): 995-1003.Find it on PubMed
Wijkstra, P. J., TenVergert, E. M., et al. (1994). "Reliability and validity of the chronic respiratory questionnaire (CRQ)." Thorax 49(5): 465-467.Find it on PubMed
Williams, J. E., Singh, S. J., et al. (2001). "Development of a self-reported Chronic Respiratory Questionnaire (CRQ-SR)." Thorax 56(12): 954-959.Find it on PubMed
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