Chronic Respiratory Disease Questionnaire (2024)

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Chronic Respiratory Disease Questionnaire (1)
  1. Rehabilitation Measures Database
  2. Chronic Respiratory Disease Questionnaire

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Chronic Respiratory Disease Questionnaire (2)

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Purpose

The Chronic Respiratory Disease Questionnaire is a disease-specific health-related quality of life questionnaire.It was developed to measure the impact of Chronic Obstructive Pulmonary Disease (COPD) on a person’s life.

Link to Instrument

Instrument Details

Acronym CRQ

Area of Assessment

Quality of Life

Assessment Type

Patient Reported Outcomes

Administration Mode

Paper & Pencil

Cost

Not Free

Cost Description

License agreement is required. Information can be found on the American Thoracic Society Website.

Diagnosis/Conditions

  • Pulmonary Disorders

Populations

Pulmonary Diseases

Non-Specific Patient Population

Key Descriptions

  • Consists of 20 items across four dimensions: dyspnea, fatigue, emotional function, and mastery.
  • Originally was administered bya clinician, but has since been modified to a self-report measure.
  • The dyspnea portion is individualized to each person: the person is asked to select the 5 activities associated with breathlessness that they perform frequently and are most important to them.
  • Dyspnea items may be selected from a list of 26 suggested items or may be written in by the patients.
  • Items in each section are scored from 1 (most severe) to 7 (no impairment).

Number of Items

20

Equipment Required

  • Copy of questionnaire
  • pen/pencil

Time to Administer

15-30minutes

30 minutes for first administration
15 minutes for subsequent administrations

Required Training

No Training

Age Ranges

Adult

18 - 64

years

Elderly Adult

65 +

years

Instrument Reviewers

Initially reviewedby Jason Barbas, PT, DPT, NCS in1/2010.

ICF Domain

Body Function

Measurement Domain

General Health

Considerations

Do you see an error or have a suggestion for this instrument summary? Pleasee-mail us!

Pulmonary Diseases

back to Populations

Minimally Clinically Important Difference (MCID)

COPD:(Redelmeier et al, 1996;n= 112 patients with COPD who were participating ina supervised respiratory rehabilitation and in stable health; mean age = 67 (10) years)

  • MCID = a change of 0.5 per item

Normative Data

COPD: (Rutten-van Molken et al, 1999; n = 144 patients with COPD, broken into three treatment groups; n = 47 taking Salmeterol and Ipatropium Bromide, 47 taking Salmeterol and placebo, and 50 taking placebo and placebo; mean age by treatment group = 63(7.1), 65.4(5.8) and 63.2(7.4) years)

Baseline characteristics of the study population

Normative Data of Study Population:

Rehabilitation group

Control group

n

28

15

Gender M/F

23/5

14/1

Age yrs

64(5)

62(5)

FEV bl

1.2(0.3)

1.2(0.3)

FEV1al

1.3(0.4)

1.4(0.3)

FEV1 % pred

44(11)

45(9)

FEV1/IVC %

39(8)

36(7)

IVC % pred

84(16)

94(15)*

TLC %pred

118(14)

114(11)

RV/TLC % pred

151(24)

133(18)*

Cstl·kPa-1

4.3(3.1)

5.3(3.0)

TLCO/VA % pred

65(23)

65(25)

All value are expressed as mean±SD. *: p<0.05 unpaired ttest. FEV1b: forced expiratory volume in one second before bronchodilation with two inhalations of 40 μg ipratropium bromide; FEV1a: FEV1 after bronchodilation; % pred: expressed as a percentage of the predicted value; FEV1/IVC %: FEV1 expressed as a percentage of the slow inspiratory vital capacity; TLC: total lung capacity; RV: residual volume; Cst: static lung compliance; TLCO/VA: transfer factor for carbon monoxide divided by alveolar volume.

Test/Retest Reliability

COPD:(Wijkstra et al, 1994;n= 43 patient with severe airflow obstruction; mean age = 64(5) years for the rehab group and 62(5) for the control group)

  • Excellenttest re-test reliability (rho = 0.90)

COPD: (Williams, 2001;n= 52 patients with COPD; mean age = 66.5(7.9) years)

  • Excellenttest re-test reliability for all four dimensions(ICC = 0.83-0.95)

Internal Consistency

COPD:(Wijkstra et al, 1994)

  • Adequateto excellentinternal consistency for all four dimensions(Cronbach's alpha = 0.71-0.88)

COPD:(Harper et al, 1997;n =76 men and 80 women with COPD attending routine outpatient clinic; mean age = 67(10.4) years for men and 62(10.3) years for women)

  • Excellentinternal consistency for all four dimensions(Cronbach's alpha = 0.8-0.85)

COPD:(Rutten-van Molken et al, 1999)

  • Excellentinternal consistency (Chronbach's alpha = 0.84)

COPD:(Hajiro et al, 1998;n= 143 men with COPD; mean age = 68.8(6.9) years)

  • Excellentinternal consistency (Chronbach's alpha = 0.90)

Construct Validity

COPD:(Hajiro et al, 1998)

  • Adequateconstruct validity with SCL-90 and SGR (r= 0.74-0.86)

Content Validity

COPD:(Wijkstra et al, 1994)

  • Poor correlations between CRQ and lung function (PFTs)
  • Poor correlations between CRQ and exercise capacity (6MW, CPET)

Responsiveness

Chronic airflow limitation:(Guyatt et al, 1987;n= 100 patients with chronic airflow limitation)

  • Responsiveness was tested by administering the questionnaire to 13 patients before and after their drug treatment and to another 28 before and after participation in a respiratory rehabilitation program
  • There were statistically significant improvements in all four dimensions

Non-Specific Patient Population

back to Populations

Minimal Detectable Change (MDC)

Quality of life:(Jaeschke et al, 1989;a literature review ofquality of life instruments)

  • A change in the score of 0.5 on the 7 point scale reflects a clinically significant small change

  • A change of 1.0 reflects a moderate change

  • A difference of 1.5 represents a large change

Minimally Clinically Important Difference (MCID)

Quality of life:(Jaeschke, 1989)

  • MCID = a change of 0.5 per item

Bibliography

Guyatt, G. H., Berman, L. B., et al. (1987). "A measure of quality of life for clinical trials in chronic lung disease." Thorax 42(10): 773-778.Find it on PubMed

Hajiro, T., Nishimura, K., et al. (1998). "Comparison of discriminative properties among disease-specific questionnaires for measuring health-related quality of life in patients with chronic obstructive pulmonary disease." Am J Respir Crit Care Med 157(3 Pt 1): 785-790.Find it on PubMed

Harper, R., Brazier, J. E., et al. (1997). "Comparison of outcome measures for patients with chronic obstructive pulmonary disease (COPD) in an outpatient setting." Thorax 52(10): 879-887.Find it on PubMed

Jaeschke, R., Singer, J., et al. (1989). "Measurement of health status. Ascertaining the minimal clinically important difference." Control Clin Trials 10(4): 407-415.Find it on PubMed

). "Assessing the minimal important difference in symptoms: a comparison of two techniques." J Clin Epidemiol 49(11): 1215-1219.Find it on PubMed

Rutten-van Molken, M., Roos, B., et al. (1999). "An empirical comparison of the St George's Respiratory Questionnaire (SGRQ) and the Chronic Respiratory Disease Questionnaire (CRQ) in a clinical trial setting." Thorax 54(11): 995-1003.Find it on PubMed

Wijkstra, P. J., TenVergert, E. M., et al. (1994). "Reliability and validity of the chronic respiratory questionnaire (CRQ)." Thorax 49(5): 465-467.Find it on PubMed

Williams, J. E., Singh, S. J., et al. (2001). "Development of a self-reported Chronic Respiratory Questionnaire (CRQ-SR)." Thorax 56(12): 954-959.Find it on PubMed

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